Anti hyperlipidemic activity of Adenanthera pavonina Linn. ethanolic bark extract fractions

C.Das, S. Dash, A.C. Sahoo, R.K. Giri, D.C. Sahoo, and P.R. Guru

Abstract

 Adenanthera pavonina Linn. (Family: Leguminoceae) otherwise called as Bead tree, Red wood (English) and Kanchan Daana, Rakta Kambal (Hindi) is utilized for many remedies traditionally. The bark is used in colonorrhea, ulcers, pharyngopathy, vitiated conditions of vata and gout and rheumatism. Lipid lowering effect of the successive fractions of ethanolic bark extracts of Adenanthera pavonina (L.) was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. The ethyl acetate fraction and n- butanol fraction of ethanolic extract at 400 mg/kg dose levels inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The extract fractions at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides in high-fat diet-induced hyperlipidemic rats. The standard dose Atrovastatin studies showed slightly better effects. The lipid lowering activity of the ethyl acetate fraction and n- butanol fraction of ethanolic extracts of Adenanthera pavonina Linn. may be attributed to the phytoconstituents present, such as triterpenoids, flavonoids, tannins, and saponins. The findings of the study reveals that ethyl acetate fraction and n- butanol fraction of ethanolic bark can effectively control the blood lipid levels in dyslipidaemic conditions by interfering with the biosynthesis of cholesterol and utilization of lipids. The main reason of the study is to find alternative and safe drugs to treat the hyperglycemia.

Key words: Adenanthera pavonina Linn., Antihyperlipidemic activity, Triton WR 1339, High-fat diet, Cholesterol, Triglyceride.

Phytochemical Composition, Anti-inflamatory and Analgesic Activities of Tecoma stans Linn. (Bignoniaceae)

S.Dash, C. Das, D.C.Sahoo, and A.C. Sahoo

Abstract

 Tecoma Stans Linn. is known to have various medicinal and therapeutic properties. Its antiinflammatory and analgesic properties were assessed in this study. The extracts and Indomethacin were found to inhibit carrageenan-induced paw oedema on albino rats with a strong activity in Indomethacin 5 mg/kg having 53.88% inhibition while Tecoma stans Linn 200 mg/kg, 400 mg/kg have 18.09% and 49.38% inhibition respectively. It elicited mild to moderate analsesic activity in acetic acid induced writhing in mice as compared with the control group. Phytochemical studies on the plants revealed the presence of bioactive components comprising flavonoids (5.70 mg. 100 g-1), alkaloids (5.40 mg. 100 g1 ), tannins (0.40 mg. 100 g-1), saponins (0.38 mg. 100 g-1) and phenols (0.10 mg. 100 g-1). These bioactive compounds may be responsible for the medicinal properties of Tecoma stans Linn. The plant thus deserves further developmental studies. Keywords: Tecoma stans Linn, Bioactive compounds, Anti inflammatory, Analgesic, ethanolic extracts.

Volume No. 1(2)                   April,2011